2004
- June 2004: Following the failure of PBS' 24-hour PBS Kids channel, which launched in 1999, PBS, HiT Entertainment, Sesame Workshop, and Comcast announce plans to launch a 24-hour preschool cable channel and video-on-demand service on Comcast.
2005
- April 4, 2005: Comcast launches Sprout On Demand, a service offering 55 hours of preschool programming in both English and Spanish.
- September 26, 2005: PBS KIDS Sprout officially launches as a linear channel.
- September 26, 2005: The debuts of Boohbah, Jay Jay the Jet Plane, Make Way for Noddy, Caillou, Sesame Street, Barney & Friends, Teletubbies, Big Sister, Little Brother, James the Cat, The Berenstain Bears, Angelina Ballerina, Pingu, Zoboomafoo, Bob the Builder, Thomas & Friends, Sagwa, the Chinese Siamese Cat, Dragon Tales, and Kipper
- September 26, 2005: The launch of The Good Night Show
- September 26, 2005: The launch of The Birthday Show
- September 26, 2005: The launch of Sproutletsgrow.com.
- September 28, 2005: Huggies and Pull-Ups Training Pants signs on as the first sponsor of Sprout.
- October 25, 2005: Andrew Beecham named SVP of original and acquired programming at Sprout.
- October 25, 2005: Sandy Wax named President of Sprout.
- October 31, 2005: Halloween on Sprout
- November 2005: Thanksgiving on Sprout
- November 28, 2005: Sprout joins Cox Communications
- December 2005: The Let's Snow Show
2006
- February 8, 2006: Chris D'Ablemont named director of ad sales at Sprout.
- March 21, 2006: Eileen Diskin named vice president of marketing at Sprout.
- April 2006: Sprout's Spring Surprise
- May 2006: Hooray for Mother's Day
- June 2006: Papa Bear's Day Celebration
- July 3, 2006: The premiere of The Many Adventures of Mr. Mailman
- July 14, 2006; TVN Entertainment and Sprout sign an on-demand agreement.
- July 20, 2006: Sprout fires Melanie Martinez from The Good Night Show shortly after a new season premieres; Good Night goes on hiatus until a new host can be found.
- September 10, 2006: The premiere of Jakers! The Adventures of Piggley Winks and Grand Tails Day
- September 11, 2006: Twenty-four "Very Special" Good Night Show episodes starring Leo, Lucy, and Star air.
- September 18, 2006: The premiere of Sprout Diner
- September 18, 2006: Dayna Hilton and Sparkles the Fire Safety Dog share fire safety tips on Sprout.
- The launch of the Fire Safety page at Sproutletsgrow.com.
- September 21, 2006: PBS KIDS Sprout's Big Birthday Surprise celebrates Sprout's 1st anniversary.
- October 2006: The premiere of Fireman Sam and Fireman Sam's Safety Special.
- October 11, 2006: Beta Research study ranks Sprout #1 in Satisfaction Ratings among all digital cable networks evaluated.
- October 2006: Sprout's Halloween Spooktacular
- November 2006: The premiere of A Sesame Street Christmas Carol
- November 23, 2006: Sprout's Thanksgiving Diner Party
- November 2006: Sprout Diner Thomas contest
- November 2006: Sproutletsgrow.com becomes SproutOnline.com.
- November 27, 2006: Annie Rex named director of interactive at Sprout
- November 27, 2006: Jeff Henry named regional vice president of marketing and new product development at Sprout.
- December 18, 2006: Nina debuts during The Good Night Show's third season.
- December 25, 2006: The premiere of The Hoobs with "Happy Hooby Holidays."
2007
- February 14, 2007: Launch of second season of The Many Adventures of Mr. Mailman.
- February 14, 2007: Sprout's Special Valentine Delivery
- March 13, 2007: "Thomas' Club Car Sandwich" named winner of Thomas contest.
- March 16, 2007: Sprout Diner March Menu commemorates the premiere of a new season of Sprout Diner.
- April 20-27, 2007: Angelina Ballerina: All Dancers On Deck and Angelina's Princess Dance premiere during Sprout's Dance Party.
- May 12-13, 2007: Hooray for Mother's Day
- June 25, 2007: The launch of The Let's Go Show
- August 22, 2007: Re-launch of SproutOnline.com.
- August 22, 2007: The launch of Sprout for Parents
- September 2007: Jakers! Grand Tails Day.
- September 10, 2007: Time Warner Cable starts to distribute Sprout.
- September 26, 2007: The launches of Musical Mornings with Coo and The Sunny Side Up Show.
- September 26, 2007: The premieres of Play With Me Sesame and Bounce.
- The Sunny Side Up Show marks the debuts of Chica and Kelly.
- September 26, 2007: The fourth season of The Good Night Show premieres, introducing Lucy Light the Way and now adds Kids to Sprout Stretch segments
- October 2007: Sprout's Halloween Spooktacular
- October 19, 2007: Second year in a row, Beta Research Study shows Sprout #1 in satisfaction among all digital cable networks evaluated.
- November 2007: Sprout's Thanksgiving Party
- November 2007: Sproutlet Thanksgiving Shorts
- November 2007: Barney Thanksgiving marathon
- December 2007: Hooray for the Holidays
- December 17, 2007: Premiere of Caillou's Holiday Movie.
- December 18, 2007: Premiere of A Christmas To Remember
- December 24, 2007: Sprout's Snooze-a-Thon
2008
- January 14, 2008: The debut of Fifi and the Flowertots
- January 16, 2008: Launch of Sprout Smart
- January 19, 2008: The debut of Panwapa
- Launch of Sprout Please
- February 14, 2008: Sprout's Special Valentine Delivery
- March 2008: Sprout Diner March Menu
- April 1, 2008: Sprout's Scrambled April Fun Day
- May 5, 2008: The launch of The Sprout Sharing Show (the debut of PICME); The Let's Go Show moves to weekend mornings.
- May 2008: Hooray for Mother's Day
- June 20, 2008: Frances premieres during Summer Fun Fridays
- June 7, 2008: The debut of Dive Olly Dive!.
- June-August 2008: Summer Fun Fridays
- July 4, 2008: The debut of Franny's Feet.
- August 6, 2008: Michael Weiss, Annie McLaughlin, Christa Mereen, and Judy Kahn on Good Sports week on The Sunny Side Up Show.
- September 2, 2008: Tom Alexander named senior vice president of marketing at Sprout.
- September 23, 2008: Launch of The Great Sprout Tuck-In
- September 26, 2008: Chica's Big Birthday Surprise
- October 13, 2008: The debut of Roary the Racing Car
- October 31, 2008: A Sweet Goodnight Treat
- November 2008: The debut of PajanimalsPajanimals
- December 2008: Preschool Musical
- December 24, 2008: Sprout's Snooze-a-Thon
- December 31, 2008: Sprout's New Year's Eve Sing Along
2009
- January 26, 2009: The debut of Mama Mirabelle's Home Movies
- February 6, 2009: New Wave Entertainment teams up with Sprout to launch Dress Chica, Dress Like Chica, and Sprout Player apps.
- February 13-14, 2009: Sprout's Super-Dee-Duper Valentine Party
- March 2009: Sprout launches accounts on YouTube, Twitter, and Facebook and podcasts on iTunes.
- April 1, 2009: Sprout's Scrambled April Fun Day
- April 2009: The Mighty Jungle premieres during Mighty Earth Week
- May 2009: Hooray for Mother's Day
- June 2009: Sprout's Smart Summer and Mr. Mailman's Summer Adventure Contest
- August 24, 2009: The launch of Sprout's Wiggly Waffle
- August 24, 2009: The debuts of Rubbadubbers and The Wiggles' first six TV series
- September 21, 2009: Sprout rebrands[1]
- September 21, 2009: New season of The Good Night Show
- October 2009: Fire Prevention Week with Dayna Hilton and Sparkles the Fire Safety Dog
- October 31, 2009: A Sweet Goodnight Treat
- November 2009: Thanks for Giving
- December 2009: Musical on Two Sticks
- December 24, 2009: Sprout's Snooze-a-Thon
- December 25, 2009: Premiere of The Show Must Go On
- December 31, 2009: Dennisha Pratt joins The Sunny Side Up Show during a Countdown to Noon.
2010
- 2010: The Let's Grow videos are released.
- February 14, 2010: Sprout's Dino-Mite Valentine’s Sing-Along
- April 1, 2010: Sprout's Scrambled April Fun Day
- April 2010: dirtgirlworld premieres during Dig Into Earth Day
- May 2010: Hooray for Mother's Day
- June 28, 2010: Nina's Little Fables premieres, replacing Make Way for Noddy.
- July 12, 2010: The debut of Chloe's Closet
- August 24, 2010: Monkey See Monkey Do premieres alongside the second season of Sprout's Wiggly Waffle.
- September 1, 2010: Sprout launches in HD
- September 25, 2010: The Sunny Side Up Show debuts on weekends; Noodle and Doodle debuts during the festivities
- October 11, 2010: Fire Prevention Week with Sparkles the Fire Safety Dog (sponsored by State Farm)
- October 31, 2010: A Sweet Goodnight Treat
- November 1, 2010: Liz Filios joins The Sunny Side Up Show.
- November 1, 2010: The debut of Driver Dan's Story Train
- December 2010: Elmo's Movie Merry-Thon
- December 24, 2010: Sprout's Snooze-a-Thon
- December 31, 2010: What's Your News? premieres on Sprout
2011
- February 14, 2011: Sprout's Dino-Mite Valentine's Day Sing-Along
- March 21, 2011: Super WHY! premieres on Sprout
- April 1, 2011: Sprout's Scrambled April Fun Day
- April 2011: Dig Into Earth Day with dirtgirlworld and Richard Blais on The Sunny Side Up Show, which reaches its 1,000th episode on April 22nd
- July 2, 2011: You Pick the PJs
- July 7, 2011: Launch of Kindness Counts
- August 16, 2011; Jose Garces helps Sprout celebrate Food Week on The Sunny Side Up Show
- September 5, 2011: LazyTown premieres on Sprout.
- October 3, 2011: Angelina Ballerina: The Next Steps premieres on Sprout.
- October 10, 2011: Full-length Pajanimals premieres on Sprout.
- October 31, 2011: A Sweet Goodnight Treat
- November 7, 2011: The premieres of Poppy Cat and a new season of The Good Night Show
- November 2011: Thanks for Giving
- December 2011: Elmo's Movie Merry-Thon
- December 24, 2011: Sprout's Snooze-a-Thon
2012
- The premiere of Abby in Wonderland
- January 2012: Save Sprout
- February 14, 2012: The launch of The Super Sproutlet Show
- February 29, 2012: The premiere of Elmo and Abby's Birthday Fun!
- April 1, 2012: Sprout's Scrambled April Fun Day
- April 22, 2012: Justin Time for Earth Week (the debut of Justin Time)
- July 7, 2012: The launch of NBC Kids
- August 27, 2012: Wibbly Pig, Olive the Ostrich, and 64 Zoo Lane premiere during Sprout's Premiere Party
- August 2012: Sprout partners with Produce for Kids
- November 24, 2012: The debut of The Chica Show
- November 26, 2012: Debut of Sprout float in Macy's Thanksgiving Day Parade; Chica appears on The Today Show on the 21st to promote.
- December 2012: Sprout hits record ratings across its competitors, with an average total day household coverage area 0.23 rating / 122k homes.
- December 24, 2012: Sprout's Snooze-a-Thon
- December 31, 2012: Cheer in the New Year
2013
- The launch of Sprout Tunes
- January 3, 2013: Mark Sacher named VP of research at Sprout.
- February 2013: From Sprout With Love
- March 25, 2013: The debut of Sid the Science Kid
- April 1, 2013: Sprout's Scrambled April Fun Day
- April 2013: Dig Into Earth Day (the debut of Tree Fu Tom)
- May 3, 2013: Sprout becomes Channel 127 on CableVision.
- June 29, 2013: Summer Splash
- July 29, 2013: New season of The Chica Show
- July 30, 2013: Host Hunt Contest
- August 19, 2013: The debut of Sarah & Duck
- September 2, 2013: The debut of Zou
- September 19, 2013: Kindest Kid Contest
- October 2013: Tricks, Clicks, and Treats
- November 1, 2013: Sprout reaches over 60 million homes with a multi market launch including New York and LA.
- November 1, 2013: Stella and Sam debuts.
- November 13, 2013: Comcast's NBCUniversal acquires a full ownership of Sprout, following a buyout of PBS, Sesame Workshop, and HiT Entertainment. As a result of this, the PBS Kids branding is no longer in the channel's name
- November 2013: Kaitlin Becker and Tim Kubart are introduced to The Sunny Side Up Show in the Macy's Thanksgiving Day Parade
- November 2013: Thanks for Giving
- December 2013: Merry Movies
- December 21, 2013: Kindest Kid Countdown
- December 24, 2013: Sprout's Snooze-a-Thon
- The Kindest Kid
2014
- January: Chica's Olympic Family Fun promotes the Sochi Winter Olympics
- February: From Sprout with Love
- March: Oscar Weekend
- March 1, 2014: The debut of Zerby Derby
- April 1, 2014: Sprout's Scrambled April Fun Day
- May 12, 2014: The debut of Lily's Driftwood Bay
- June 9, 2014: The launch of Sprout Control Room
- July 12, 2014: The debut of Astroblast!
- Sprout launches The More You Know PSAs
- August 16, 2014: The debut of Earth to Luna!
- October 11, 2014: The debut of Boj
- October 25, 2014: New season of Poppy Cat
- October: Tricks, Clicks, and Treats
- November 1, 2014: Pajanimals Pajama Party
- November 2014: Thanks for Giving
- December 2014: Merry Movies
- December 2014: Kindest Kid Countdown
- December 24, 2014: Sprout's Snooze-a-Thon
- Kindest Kid Contest
2015
- February 14, 2015: The debut of Ruff-Ruff, Tweet and Dave
- February: Oscar Weekend
- March 14, 2015: The debut of Super Wings
- April 1, 2015: Sprout's Scrambled April Fun Day
- June 9, 2015: The Sunny Side Up Show reaches 2,500 episodes.
- June 20, 2015: The debut of Clangers
- June-August, 2015: Summer of Sprout
- July 27, 2015: New season of The Good Night Show
- September 26, 2015: Sprout rebrands for its tenth anniversary
- September 26, 2015: Setting change to The Sunny Side Up Show (city apartment) and name shortening to Sunny Side Up.
- September 26, 2015: The debuts of Nina's World, Maya the Bee, and Sydney Sailboat
- December 24, 2015: Sprout's Snooze-a-Thon
2016
- Amy Friedman named SVP of Programming at Sprout
- Deirdre Brennan named President of Sprout
- January 23, 2016: The debut of Floogals
- February 13, 14, 27, & 28: DinoMax: The Land Before Time Movie Megathon
- February 20, 2016: The debut of YaYa and Zouk
- March 7, 2016: The debut of Little People
- March 19, 2016: The debut of The Jungle Bunch
- May 28, 2016: The debut of Doozers
- July 9, 2016: The debut of Terrific Trucks
- September 3, 2016: The debut of Noddy: Toyland Detective
- September 26, 2016: Back to New
- September 28, 2016: The Furchester Hotel premieres on Sprout.
- October: Sprout's Knock Knock Joke Halloween and Sprout Dream Halloween Costume
- October 22, 2016: Dot. premieres on Sprout.
- November 5, 2016: Space Racers premieres on Sprout.
- December: Holidays Unwrapped
- Imagination Comes to Life
2017
- Sprout's Most Awesome Adventures
- January: Deirdre Brennan named general manager of Sprout
- January: Dea Connick Perez, Shane Lindley, and Chanon Cook join Sprout as Vice Presidents of program strategy and acquisition, digital, and insights and strategy respectively.
- January 15: The debut of The Land Before Time
- February: Valentine's BFFs
- February: I Am the New History
- May 27, 2017: The debut of The Ollie and Moon Show
- It's Not Summer Without Sprout
- June 17, 2017: The debut of Topsy and Tim
- July 8, 2017: The debut of Ranger Rob
- July 15, 2017: The debut of Kody Kapow
- July 17, 2017: The debut of Masha and the Bear
- August 12, 2017: The debut of School of Roars
- August 14, 2017: The debut of Sprout House (later Snug's House)
- September 9, 2017: The original Sprout channel closes down in favor of Universal Kids.